Center for Alzheimer's and Neurodegenerative Diseases

Fingerprint The fingerprint is based on mining the text of the scientific documents related to the associated persons. Based on that an index of weighted terms is created, which defines the key subjects of research unit

Tauopathies Medicine & Life Sciences
Prions Medicine & Life Sciences
Pathology Medicine & Life Sciences
Alzheimer Disease Medicine & Life Sciences
Seeds Medicine & Life Sciences
Brain Medicine & Life Sciences
Amyloid Medicine & Life Sciences
Neurodegenerative Diseases Medicine & Life Sciences

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Research Output 2015 2018

DNP-Assisted NMR Investigation of Proteins at Endogenous Levels in Cellular Milieu

Costello, W. N., Xiao, Y. & Frederick, K. K., Jan 1 2018, (Accepted/In press) In : Methods in Enzymology.

Research output: Contribution to journalArticle

Magnetic Resonance Spectroscopy
Nuclear magnetic resonance
Polarization
Proteins
Biomolecules
4 Citations

Inert and seed-competent tau monomers suggest structural origins of aggregation

Mirbaha, H., Chen, D., Morazova, O. A., Ruff, K. M., Sharma, A. M., Liu, X., Goodarzi, M., Pappu, R. V., Colby, D. W., Mirzaei, H., Joachimiak, L. A. & Diamond, M. I., Jul 10 2018, In : eLife. 7, e36584.

Research output: Contribution to journalArticle

Seed
Seeds
Agglomeration
Monomers
Tauopathies
9 Citations

Profilin reduces aggregation and phase separation of huntingtin N-terminal fragments by preferentially binding to soluble monomers and oligomers

Posey, A. E., Ruff, K. M., Harmon, T. S., Crick, S. L., Li, A., Diamond, M. I. & Pappu, R. V., Jan 1 2018, In : Journal of Biological Chemistry. 293, 10, p. 3734-3746 13 p.

Research output: Contribution to journalArticle

Profilins
Oligomers
Phase separation
Agglomeration
Monomers