Pharmacology - Lehrman Lab

Fingerprint The fingerprint is based on mining the text of the scientific documents related to the associated persons. Based on that an index of weighted terms is created, which defines the key subjects of research unit

Dolichol Medicine & Life Sciences
Oligosaccharides Medicine & Life Sciences
Glycosylation Medicine & Life Sciences
Lipids Medicine & Life Sciences
Mannose Medicine & Life Sciences
Cricetinae Medicine & Life Sciences
Endoplasmic Reticulum Medicine & Life Sciences
Transferases Medicine & Life Sciences

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Research Output 1985 2016

1 Citations

Oligosaccharyltransferase inhibition induces senescence in RTK-driven tumor cells

Lopez-Sambrooks, C., Shrimal, S., Khodier, C., Flaherty, D. P., Rinis, N., Charest, J. C., Gao, N., Zhao, P., Wells, L., Lewis, T. A., Lehrman, M. A., Gilmore, R., Golden, J. E. & Contessa, J. N. Oct 3 2016 In : Nature Chemical Biology.

Research output: Contribution to journalArticle

Neoplasms
Glycosylation
Epidermal Growth Factor Receptor
Glycoproteins
Cell Line
4 Citations

Trappc11 is required for protein glycosylation in zebrafish and humans

DeRossi, C., Vacaru, A., Rafiq, R., Cinaroglu, A., Imriea, D., Nayar, S., Baryshnikova, A., Milev, M. P., Stanga, D., Kadakia, D., Gao, N., Chu, J., Freeze, H. H., Lehrman, M. A., Sacher, M. & Sadler, K. C. Apr 15 2016 In : Molecular Biology of the Cell. 27, 8, p. 1220-1234 15 p.

Research output: Contribution to journalArticle

Unfolded Protein Response
Zebrafish
Glycosylation
Oligosaccharides
Lipids
19 Citations

Cytosolic Nuclease TREX1 Regulates Oligosaccharyltransferase Activity Independent of Nuclease Activity to Suppress Immune Activation

Hasan, M., Fermaintt, C. S., Gao, N., Sakai, T., Miyazaki, T., Jiang, S., Li, Q. Z., Atkinson, J. P., Morse, H. C., Lehrman, M. A. & Yan, N. Sep 15 2015 In : Immunity. 43, 3, p. 463-474 12 p., 3143

Research output: Contribution to journalArticle

Frameshift Mutation
Deoxyribonucleases
Endoplasmic Reticulum
Polysaccharides
Mutation