Pharmacology - Lehrman Lab

Fingerprint The fingerprint is based on mining the text of the scientific documents related to the associated persons. Based on that an index of weighted terms is created, which defines the key subjects of research unit

Dolichol Medicine & Life Sciences
Glycosylation Medicine & Life Sciences
Proteins Chemical Compounds
Endoplasmic Reticulum Medicine & Life Sciences
lipid-linked oligosaccharides Medicine & Life Sciences
Oligosaccharides Medicine & Life Sciences
Cricetinae Medicine & Life Sciences
Cricetulus Medicine & Life Sciences

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Research Output 1985 2016

4 Citations

Oligosaccharyltransferase inhibition induces senescence in RTK-driven tumor cells

Lopez-Sambrooks, C., Shrimal, S., Khodier, C., Flaherty, D. P., Rinis, N., Charest, J. C., Gao, N., Zhao, P., Wells, L., Lewis, T. A., Lehrman, M. A., Gilmore, R., Golden, J. E. & Contessa, J. N. Oct 3 2016 (Accepted/In press) In : Nature Chemical Biology.

Research output: Research - peer-reviewArticle

dolichyl-diphosphooligosaccharide - protein glycotransferase
Epidermal Growth Factor Receptor
6 Citations

Trappc11 is required for protein glycosylation in zebrafish and humans

DeRossi, C., Vacaru, A., Rafiq, R., Cinaroglu, A., Imriea, D., Nayar, S., Baryshnikova, A., Milev, M. P., Stanga, D., Kadakia, D., Gao, N., Chu, J., Freeze, H. H., Lehrman, M. A., Sacher, M. & Sadler, K. C. Apr 15 2016 In : Molecular Biology of the Cell. 27, 8, p. 1220-1234 15 p.

Research output: Research - peer-reviewArticle

Unfolded Protein Response
lipid-linked oligosaccharides
Carrier Proteins
21 Citations

Cytosolic Nuclease TREX1 Regulates Oligosaccharyltransferase Activity Independent of Nuclease Activity to Suppress Immune Activation

Hasan, M., Fermaintt, C. S., Gao, N., Sakai, T., Miyazaki, T., Jiang, S., Li, Q. Z., Atkinson, J. P., Morse, H. C., Lehrman, M. A. & Yan, N. Sep 15 2015 In : Immunity. 43, 3, p. 463-474 12 p., 3143

Research output: Research - peer-reviewArticle

dolichyl-diphosphooligosaccharide - protein glycotransferase
Frameshift Mutation
Endoplasmic Reticulum