Pharmacology - Lehrman Lab

Fingerprint The fingerprint is based on mining the text of the scientific documents related to the associated persons. Based on that an index of weighted terms is created, which defines the key subjects of research unit

Dolichol Medicine & Life Sciences
Glycosylation Chemical Compounds
Oligosaccharides Medicine & Life Sciences
Unfolded Protein Response Medicine & Life Sciences
Endoplasmic Reticulum Medicine & Life Sciences
Cricetulus Medicine & Life Sciences
Cricetinae Medicine & Life Sciences
Transferases Chemical Compounds

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Research Output 1985 2018

Mammalian STT3A/B oligosaccharyltransferases segregate N-glycosylation at the translocon from lipid-linked oligosaccharide hydrolysis

Lu, H., Fermaintt, C. S., Cherepanova, N. A., Reid, G., Yan, N. & Lehrman, M. A., Sep 18 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 38, p. 9557-9562 6 p.

Research output: Contribution to journalArticle

Glycosylation
Hydrolysis
Oligosaccharides
lipid-linked oligosaccharides
dolichyl-diphosphooligosaccharide - protein glycotransferase
11 Citations

Oligosaccharyltransferase inhibition induces senescence in RTK-driven tumor cells

Lopez-Sambrooks, C., Shrimal, S., Khodier, C., Flaherty, D. P., Rinis, N., Charest, J. C., Gao, N., Zhao, P., Wells, L., Lewis, T. A., Lehrman, M. A., Gilmore, R., Golden, J. E. & Contessa, J. N., Oct 3 2016, (Accepted/In press) In : Nature Chemical Biology.

Research output: Contribution to journalArticle

Neoplasms
Glycosylation
Epidermal Growth Factor Receptor
Glycoproteins
Cell Line
11 Citations

Trappc11 is required for protein glycosylation in zebrafish and humans

DeRossi, C., Vacaru, A., Rafiq, R., Cinaroglu, A., Imriea, D., Nayar, S., Baryshnikova, A., Milev, M. P., Stanga, D., Kadakia, D., Gao, N., Chu, J., Freeze, H. H., Lehrman, M. A., Sacher, M. & Sadler, K. C., Apr 15 2016, In : Molecular Biology of the Cell. 27, 8, p. 1220-1234 15 p.

Research output: Contribution to journalArticle

Unfolded Protein Response
Zebrafish
Glycosylation
Carrier Proteins
Terpenes