Pharmacology - Wilkie Lab

Fingerprint The fingerprint is based on mining the text of the scientific documents related to the associated persons. Based on that an index of weighted terms is created, which defines the key subjects of research unit

GTP-Binding Proteins Medicine & Life Sciences
RGS Proteins Medicine & Life Sciences
GTP-Binding Protein Regulators Medicine & Life Sciences
Proteins Medicine & Life Sciences
Genes Medicine & Life Sciences
GTPase-Activating Proteins Medicine & Life Sciences
GTP-Binding Protein alpha Subunits Medicine & Life Sciences
Knockout Mice Medicine & Life Sciences

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Research Output 1991 2016

2 Citations

The synthetic diazonamide DZ-2384 has distinct effects on microtubule curvature and dynamics without neurotoxicity

Wieczorek, M. , Tcherkezian, J. , Bernier, C. , Prota, A. E. , Chaaban, S. , Rolland, Y. , Godbout, C. , Hancock, M. A. , Arezzo, J. C. , Ocal, O. , Rocha, C. , Olieric, N. , Hall, A. , Ding, H. , Bramoullé, A. , Annis, M. G. , Zogopoulos, G. , Harran, P. G. , Wilkie, T. M. , Brekken, R. A. & 5 others Siegel, P. M., Steinmetz, M. O., Shore, G. C., Brouhard, G. J. & Roulston, A. Nov 16 2016 In : Science Translational Medicine. 8, 365

Research output: Contribution to journalArticle

Microtubules
Tubulin
Safety
Vinca Alkaloids
X Ray Crystallography
4 Citations

A rapid in vivo screen for pancreatic ductal adenocarcinoma therapeutics

Ocal, O., Pashkov, V., Kollipara, R. K., Zolghadri, Y., Cruz, V. H., Hale, M. A., Heath, B. R., Artyukhin, A. B., Christie, A. L., Tsoulfas, P., Lorens, J. B., Swift, G. H., Brekken, R. A. & Wilkie, T. M. Oct 1 2015 In : DMM Disease Models and Mechanisms. 8, 10, p. 1201-1211 11 p.

Research output: Contribution to journalArticle

Adenocarcinoma
Neoplasms
Contraception Behavior
Anthralin
G-Protein-Coupled Receptors
3 Citations

The G protein Gα11 is essential for hypertrophic signalling in diabetic myocardium

Reuter, H., Seuthe, K., Korkmaz, Y., Grönke, S., Hoyer, D. P., Rottlaender, D., Zobel, C., Addicks, K., Hoyer, J., Grimminger, P., Brabender, J., Wilkie, T. M. & Erdmann, E. Aug 20 2013 In : International Journal of Cardiology. 167, 4, p. 1476-1485 10 p.

Research output: Contribution to journalArticle

GTP-Binding Proteins
Knockout Mice
Myocardium
Protein Kinase C-epsilon
Calcineurin