• 4998 Citations
  • 39 h-Index
1987 …2018
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Fingerprint Fingerprint is based on mining the text of the experts' scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

  • 5 Similar Profiles
Trypanosoma brucei brucei Medicine & Life Sciences
Ornithine Decarboxylase Medicine & Life Sciences
Adenosylmethionine Decarboxylase Medicine & Life Sciences
Enzymes Medicine & Life Sciences
Plasmodium falciparum Medicine & Life Sciences
Polyamines Medicine & Life Sciences
Parasites Medicine & Life Sciences
African Trypanosomiasis Medicine & Life Sciences

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Research Output 1987 2018

  • 4998 Citations
  • 39 h-Index
  • 119 Article
  • 2 Chapter
  • 1 Short survey
  • 1 Review article
Adenosylmethionine Decarboxylase
Trypanosoma brucei brucei
S-Adenosylmethionine
Polyamines
Enzymes
5 Citations

Antimalarial activity of single-dose DSM265, a novel plasmodium dihydroorotate dehydrogenase inhibitor, in patients with uncomplicated Plasmodium falciparum or Plasmodium vivax malaria infection: a proof-of-concept, open-label, phase 2a study

Llanos-Cuentas, A., Casapia, M., Chuquiyauri, R., Hinojosa, J. C., Kerr, N., Rosario, M., Toovey, S., Arch, R. H., Phillips, M. A., Rozenberg, F. D., Bath, J., Ng, C. L., Cowell, A. N., Winzeler, E. A., Fidock, D. A., Baker, M., Möhrle, J. J., Hooft van Huijsduijnen, R., Gobeau, N., Araeipour, N. & 3 othersAndenmatten, N., Rückle, T. & Duparc, S., Jan 1 2018, (Accepted/In press) In : The Lancet Infectious Diseases.

Research output: Contribution to journalArticle

Vivax Malaria
Plasmodium
Antimalarials
Plasmodium falciparum
Infection

Identification and Mechanistic Understanding of Dihydroorotate Dehydrogenase Point Mutations in Plasmodium falciparum that Confer in Vitro Resistance to the Clinical Candidate DSM265

White, J., Dhingra, S. K., Deng, X., El Mazouni, F., Lee, M. C. S., Afanador, G. A., Lawong, A., Tomchick, D. R., Ng, C. L., Bath, J., Rathod, P. K., Fidock, D. A. & Phillips, M. A., Jan 1 2018, (Accepted/In press) In : ACS Infectious Diseases.

Research output: Contribution to journalArticle

Plasmodium falciparum
Point Mutation
Parasites
Malaria
Mutation
2 Citations

Isoxazolopyrimidine-Based Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase with Antimalarial Activity

Kokkonda, S., El Mazouni, F., White, K. L., White, J., Shackleford, D. M., Lafuente-Monasterio, M. J., Rowland, P., Manjalanagara, K., Joseph, J. T., Garcia-Pérez, A., Fernandez, J., Gamo, F. J., Waterson, D., Burrows, J. N., Palmer, M. J., Charman, S. A., Rathod, P. K. & Phillips, M. A., Aug 31 2018, In : ACS Omega. 3, 8, p. 9227-9240 14 p.

Research output: Contribution to journalArticle

Antimalarials
Pharmacokinetics
Pharmaceutical Preparations
Lead
dihydroorotate dehydrogenase
1 Citations

Polyamines in protozoan pathogens

Phillips, M. A., Jan 1 2018, In : Journal of Biological Chemistry. 293, 48, p. 18746-18756 11 p.

Research output: Contribution to journalReview article

Polyamines
Pathogens
African Trypanosomiasis
Biosynthetic Pathways
Metabolism