2016 American College of Rheumatology/European League Against Rheumatism Criteria for Minimal, Moderate, and Major Clinical Response in Juvenile Dermatomyositis: An International Myositis Assessment and Clinical Studies Group/Paediatric Rheumatology International Trials Organisation Collaborative Initiative

Lisa G. Rider, Rohit Aggarwal, Angela Pistorio, Nastaran Bayat, Brian Erman, Brian M. Feldman, Adam M. Huber, Rolando Cimaz, Rubén J. Cuttica, Sheila Knupp de Oliveira, Carol B. Lindsley, Clarissa A. Pilkington, Marilynn Punaro, Angelo Ravelli, Ann M. Reed, Kelly Rouster-Stevens, Annet van Royen-Kerkhof, Frank Dressler, Claudia Saad Magalhaes, Tamás Constantin & 184 others Joyce E. Davidson, Bo Magnusson, Ricardo Russo, Luca Villa, Mariangela Rinaldi, Howard Rockette, Peter A. Lachenbruch, Frederick W. Miller, Jiri Vencovsky, Nicolino Ruperto, Lisa G. Rider, Nicolino Ruperto, Frederick W. Miller, Jiri Vencovsky, Rohit Aggarwal, Brian Erman, Nastaran Bayat, Angela Pistorio, Adam M. Huber, Brian M. Feldman, Paul Hansen, Howard Rockette, Peter A. Lachenbruch, Nicolino Ruperto, Lisa G. Rider, Maria Apaz, Suzanne Bowyer, Rolando Cimaz, Tamás Constantin, Megan Curran, Joyce Davidson, Brian M. Feldman, Thomas Griffin, Adam H. Huber, Olcay Jones, Susan Kim, Bianca Lang, Carol Lindsley, Daniel Lovell, Claudia Saad Magalhaes, Lauren M. Pachman, Clarissa Pilkington, Andrea Ponyi, Marilynn Punaro, Pierre Quartier, Athimalaipet V. Ramanan, Angelo Ravelli, Ann Reed, Robert Rennebohm, David D. Sherry, Clovis A. Silva, Elizabeth Stringer, Annet van Royen-Kerkhof, Carol Wallace, Frederick W. Miller, Chester V. Oddis, Ann Reed, Lisa G. Rider, Nicolino Ruperto, Maria Apaz, Tadej Avcin, Mara Becker, Michael W. Beresford, Rolando Cimaz, Tamás Constantin, Megan Curran, Ruben Cuttica, Joyce Davidson, Frank Dressler, Jeffrey Dvergsten, Sheila Knupp Feitosa de Oliveira, Brian M. Feldman, Virginia Paes Leme Ferriani, Berit Flato, Valeria Gerloni, Thomas Griffin, Michael Henrickson, Claas Hinze, Mark Hoeltzel, Adam M. Huber, Maria Ibarra, Norman Ilowite, Lisa Imundo, Olcay Jones, Susan Kim, Daniel Kingsbury, Bianca Lang, Carol Lindsley, Daniel Lovell, Alberto Martini, Claudia Saad Magalhaes, Bo Magnusson, Sheilagh Maguiness, Susan Maillard, Pernille Mathiesen, Liza McCann, Susan Nielsen, Lauren M. Pachman, Murray Passo, Clarissa Pilkington, Marilynn Punaro, Pierre Quartier, Egla Rabinovich, Athimalaipet V. Ramanan, Angelo Ravelli, Ann Reed, Robert Rennebohm, Lisa G. Rider, Rafael Rivas-Chacon, Angela Byun Robinson, Kelly Rouster-Stevens, Ricardo Russo, Lidia Rutkowska-Sak, Adriana Sallum, Helga Sanner, Heinrike Schmeling, Duygu Selcen, Bracha Shaham, David D. Sherry, Clovis A. Silva, Charles H. Spencer, Robert Sundel, Marc Tardieu, Akaluck Thatayatikom, Janjaap van der Net, Annet van Royen-Kerkhof, Dawn Wahezi, Carol Wallace, Francesco Zulian, Conjoint analysis, Rolando Cimaz, Tamás Constantin, Ruben Cuttica, Joyce Davidson, Frank Dressler, Sheila Knupp Feitosa de Oliveira, Brian M. Feldman, Thomas Griffin, Michael Henrickson, Adam M. Huber, Lisa Imundo, Bianca Lang, Carol Lindsley, Claudia Saad Magalhaes, Bo Magnusson, Susan Maillard, Lauren M. Pachman, Murray Passo, Clarissa Pilkington, Marilynn Punaro, Angelo Ravelli, Ann Reed, Lisa G. Rider, Kelly Rouster-Stevens, Ricardo Russo, Bracha Shaham, Robert Sundel, Janjaap van der Net, Annet van Royen-Kerkhof, Rolando Cimaz, Rubén Cuttica, Sheila Knupp Feitosa de Oliveira, Brian M. Feldman, Adam M. Huber, Carol B. Lindsley, Clarissa Pilkington, Marilynn Punaro, Angelo Ravelli, Ann Reed, Kelly Rouster-Stevens, Annet van Royen-Kerkhof, Anthony Amato, Hector Chinoy, Robert G. Cooper, Maryam Dastmalchi, Marianne de Visser, David Fiorentino, David Isenberg, James Katz, Andrew Mammen, Chester V. Oddis, Jiri Vencovsky, Steven R. Ytterberg,

Research output: Contribution to journalArticle

  • 2 Citations

Abstract

Objective: To develop response criteria for juvenile dermatomyositis (DM). Methods: We analyzed the performance of 312 definitions that used core set measures from either the International Myositis Assessment and Clinical Studies Group (IMACS) or the Paediatric Rheumatology International Trials Organisation (PRINTO) and were derived from natural history data and a conjoint analysis survey. They were further validated using data from the PRINTO trial of prednisone alone compared to prednisone with methotrexate or cyclosporine and the Rituximab in Myositis (RIM) trial. At a consensus conference, experts considered 14 top candidate criteria based on their performance characteristics and clinical face validity, using nominal group technique. Results: Consensus was reached for a conjoint analysis–based continuous model with a total improvement score of 0–100, using absolute percent change in core set measures of minimal (≥30), moderate (≥45), and major (≥70) improvement. The same criteria were chosen for adult DM/polymyositis, with differing thresholds for improvement. The sensitivity and specificity were 89% and 91–98% for minimal improvement, 92–94% and 94–99% for moderate improvement, and 91–98% and 85–86% for major improvement, respectively, in juvenile DM patient cohorts using the IMACS and PRINTO core set measures. These criteria were validated in the PRINTO trial for differentiating between treatment arms for minimal and moderate improvement (P = 0.009–0.057) and in the RIM trial for significantly differentiating the physician's rating for improvement (P < 0.006). Conclusion: The response criteria for juvenile DM consisted of a conjoint analysis–based model using a continuous improvement score based on absolute percent change in core set measures, with thresholds for minimal, moderate, and major improvement.

Original languageEnglish (US)
Pages (from-to)911-923
Number of pages13
JournalArthritis and Rheumatology
Volume69
Issue number5
DOIs
StatePublished - May 1 2017

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Myositis
Dermatomyositis
Rheumatology
Pediatrics
Prednisone
Methotrexate
Cyclosporine
Physicians

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology

Cite this

Rider, L. G., Aggarwal, R., Pistorio, A., Bayat, N., Erman, B., Feldman, B. M., ... for the International Myositis Assessment and Clinical Studies Group and the Paediatric Rheumatology International Trials Organisation (2017). 2016 American College of Rheumatology/European League Against Rheumatism Criteria for Minimal, Moderate, and Major Clinical Response in Juvenile Dermatomyositis: An International Myositis Assessment and Clinical Studies Group/Paediatric Rheumatology International Trials Organisation Collaborative Initiative. Arthritis and Rheumatology, 69(5), 911-923. DOI: 10.1002/art.40060

2016 American College of Rheumatology/European League Against Rheumatism Criteria for Minimal, Moderate, and Major Clinical Response in Juvenile Dermatomyositis : An International Myositis Assessment and Clinical Studies Group/Paediatric Rheumatology International Trials Organisation Collaborative Initiative. / Rider, Lisa G.; Aggarwal, Rohit; Pistorio, Angela; Bayat, Nastaran; Erman, Brian; Feldman, Brian M.; Huber, Adam M.; Cimaz, Rolando; Cuttica, Rubén J.; de Oliveira, Sheila Knupp; Lindsley, Carol B.; Pilkington, Clarissa A.; Punaro, Marilynn; Ravelli, Angelo; Reed, Ann M.; Rouster-Stevens, Kelly; van Royen-Kerkhof, Annet; Dressler, Frank; Magalhaes, Claudia Saad; Constantin, Tamás; Davidson, Joyce E.; Magnusson, Bo; Russo, Ricardo; Villa, Luca; Rinaldi, Mariangela; Rockette, Howard; Lachenbruch, Peter A.; Miller, Frederick W.; Vencovsky, Jiri; Ruperto, Nicolino; Rider, Lisa G.; Ruperto, Nicolino; Miller, Frederick W.; Vencovsky, Jiri; Aggarwal, Rohit; Erman, Brian; Bayat, Nastaran; Pistorio, Angela; Huber, Adam M.; Feldman, Brian M.; Hansen, Paul; Rockette, Howard; Lachenbruch, Peter A.; Ruperto, Nicolino; Rider, Lisa G.; Apaz, Maria; Bowyer, Suzanne; Cimaz, Rolando; Constantin, Tamás; Curran, Megan; Davidson, Joyce; Feldman, Brian M.; Griffin, Thomas; Huber, Adam H.; Jones, Olcay; Kim, Susan; Lang, Bianca; Lindsley, Carol; Lovell, Daniel; Saad Magalhaes, Claudia; Pachman, Lauren M.; Pilkington, Clarissa; Ponyi, Andrea; Punaro, Marilynn; Quartier, Pierre; Ramanan, Athimalaipet V.; Ravelli, Angelo; Reed, Ann; Rennebohm, Robert; Sherry, David D.; Silva, Clovis A.; Stringer, Elizabeth; van Royen-Kerkhof, Annet; Wallace, Carol; Miller, Frederick W.; Oddis, Chester V.; Reed, Ann; Rider, Lisa G.; Ruperto, Nicolino; Apaz, Maria; Avcin, Tadej; Becker, Mara; Beresford, Michael W.; Cimaz, Rolando; Constantin, Tamás; Curran, Megan; Cuttica, Ruben; Davidson, Joyce; Dressler, Frank; Dvergsten, Jeffrey; Feitosa de Oliveira, Sheila Knupp; Feldman, Brian M.; Leme Ferriani, Virginia Paes; Flato, Berit; Gerloni, Valeria; Griffin, Thomas; Henrickson, Michael; Hinze, Claas; Hoeltzel, Mark; Huber, Adam M.; Ibarra, Maria; Ilowite, Norman; Imundo, Lisa; Jones, Olcay; Kim, Susan; Kingsbury, Daniel; Lang, Bianca; Lindsley, Carol; Lovell, Daniel; Martini, Alberto; Saad Magalhaes, Claudia; Magnusson, Bo; Maguiness, Sheilagh; Maillard, Susan; Mathiesen, Pernille; McCann, Liza; Nielsen, Susan; Pachman, Lauren M.; Passo, Murray; Pilkington, Clarissa; Punaro, Marilynn; Quartier, Pierre; Rabinovich, Egla; Ramanan, Athimalaipet V.; Ravelli, Angelo; Reed, Ann; Rennebohm, Robert; Rider, Lisa G.; Rivas-Chacon, Rafael; Byun Robinson, Angela; Rouster-Stevens, Kelly; Russo, Ricardo; Rutkowska-Sak, Lidia; Sallum, Adriana; Sanner, Helga; Schmeling, Heinrike; Selcen, Duygu; Shaham, Bracha; Sherry, David D.; Silva, Clovis A.; Spencer, Charles H.; Sundel, Robert; Tardieu, Marc; Thatayatikom, Akaluck; van der Net, Janjaap; van Royen-Kerkhof, Annet; Wahezi, Dawn; Wallace, Carol; Zulian, Francesco; analysis, Conjoint; Cimaz, Rolando; Constantin, Tamás; Cuttica, Ruben; Davidson, Joyce; Dressler, Frank; Knupp Feitosa de Oliveira, Sheila; Feldman, Brian M.; Griffin, Thomas; Henrickson, Michael; Huber, Adam M.; Imundo, Lisa; Lang, Bianca; Lindsley, Carol; Saad Magalhaes, Claudia; Magnusson, Bo; Maillard, Susan; Pachman, Lauren M.; Passo, Murray; Pilkington, Clarissa; Punaro, Marilynn; Ravelli, Angelo; Reed, Ann; Rider, Lisa G.; Rouster-Stevens, Kelly; Russo, Ricardo; Shaham, Bracha; Sundel, Robert; van der Net, Janjaap; van Royen-Kerkhof, Annet; Cimaz, Rolando; Cuttica, Rubén; Knupp Feitosa de Oliveira, Sheila; Feldman, Brian M.; Huber, Adam M.; Lindsley, Carol B.; Pilkington, Clarissa; Punaro, Marilynn; Ravelli, Angelo; Reed, Ann; Rouster-Stevens, Kelly; van Royen-Kerkhof, Annet; Amato, Anthony; Chinoy, Hector; Cooper, Robert G.; Dastmalchi, Maryam; de Visser, Marianne; Fiorentino, David; Isenberg, David; Katz, James; Mammen, Andrew; Oddis, Chester V.; Vencovsky, Jiri; Ytterberg, Steven R.; for the International Myositis Assessment and Clinical Studies Group and the Paediatric Rheumatology International Trials Organisation.

In: Arthritis and Rheumatology, Vol. 69, No. 5, 01.05.2017, p. 911-923.

Research output: Contribution to journalArticle

Rider, LG, Aggarwal, R, Pistorio, A, Bayat, N, Erman, B, Feldman, BM, Huber, AM, Cimaz, R, Cuttica, RJ, de Oliveira, SK, Lindsley, CB, Pilkington, CA, Punaro, M, Ravelli, A, Reed, AM, Rouster-Stevens, K, van Royen-Kerkhof, A, Dressler, F, Magalhaes, CS, Constantin, T, Davidson, JE, Magnusson, B, Russo, R, Villa, L, Rinaldi, M, Rockette, H, Lachenbruch, PA, Miller, FW, Vencovsky, J, Ruperto, N, Rider, LG, Ruperto, N, Miller, FW, Vencovsky, J, Aggarwal, R, Erman, B, Bayat, N, Pistorio, A, Huber, AM, Feldman, BM, Hansen, P, Rockette, H, Lachenbruch, PA, Ruperto, N, Rider, LG, Apaz, M, Bowyer, S, Cimaz, R, Constantin, T, Curran, M, Davidson, J, Feldman, BM, Griffin, T, Huber, AH, Jones, O, Kim, S, Lang, B, Lindsley, C, Lovell, D, Saad Magalhaes, C, Pachman, LM, Pilkington, C, Ponyi, A, Punaro, M, Quartier, P, Ramanan, AV, Ravelli, A, Reed, A, Rennebohm, R, Sherry, DD, Silva, CA, Stringer, E, van Royen-Kerkhof, A, Wallace, C, Miller, FW, Oddis, CV, Reed, A, Rider, LG, Ruperto, N, Apaz, M, Avcin, T, Becker, M, Beresford, MW, Cimaz, R, Constantin, T, Curran, M, Cuttica, R, Davidson, J, Dressler, F, Dvergsten, J, Feitosa de Oliveira, SK, Feldman, BM, Leme Ferriani, VP, Flato, B, Gerloni, V, Griffin, T, Henrickson, M, Hinze, C, Hoeltzel, M, Huber, AM, Ibarra, M, Ilowite, N, Imundo, L, Jones, O, Kim, S, Kingsbury, D, Lang, B, Lindsley, C, Lovell, D, Martini, A, Saad Magalhaes, C, Magnusson, B, Maguiness, S, Maillard, S, Mathiesen, P, McCann, L, Nielsen, S, Pachman, LM, Passo, M, Pilkington, C, Punaro, M, Quartier, P, Rabinovich, E, Ramanan, AV, Ravelli, A, Reed, A, Rennebohm, R, Rider, LG, Rivas-Chacon, R, Byun Robinson, A, Rouster-Stevens, K, Russo, R, Rutkowska-Sak, L, Sallum, A, Sanner, H, Schmeling, H, Selcen, D, Shaham, B, Sherry, DD, Silva, CA, Spencer, CH, Sundel, R, Tardieu, M, Thatayatikom, A, van der Net, J, van Royen-Kerkhof, A, Wahezi, D, Wallace, C, Zulian, F, analysis, C, Cimaz, R, Constantin, T, Cuttica, R, Davidson, J, Dressler, F, Knupp Feitosa de Oliveira, S, Feldman, BM, Griffin, T, Henrickson, M, Huber, AM, Imundo, L, Lang, B, Lindsley, C, Saad Magalhaes, C, Magnusson, B, Maillard, S, Pachman, LM, Passo, M, Pilkington, C, Punaro, M, Ravelli, A, Reed, A, Rider, LG, Rouster-Stevens, K, Russo, R, Shaham, B, Sundel, R, van der Net, J, van Royen-Kerkhof, A, Cimaz, R, Cuttica, R, Knupp Feitosa de Oliveira, S, Feldman, BM, Huber, AM, Lindsley, CB, Pilkington, C, Punaro, M, Ravelli, A, Reed, A, Rouster-Stevens, K, van Royen-Kerkhof, A, Amato, A, Chinoy, H, Cooper, RG, Dastmalchi, M, de Visser, M, Fiorentino, D, Isenberg, D, Katz, J, Mammen, A, Oddis, CV, Vencovsky, J, Ytterberg, SR & for the International Myositis Assessment and Clinical Studies Group and the Paediatric Rheumatology International Trials Organisation 2017, '2016 American College of Rheumatology/European League Against Rheumatism Criteria for Minimal, Moderate, and Major Clinical Response in Juvenile Dermatomyositis: An International Myositis Assessment and Clinical Studies Group/Paediatric Rheumatology International Trials Organisation Collaborative Initiative' Arthritis and Rheumatology, vol 69, no. 5, pp. 911-923. DOI: 10.1002/art.40060

Rider, Lisa G.; Aggarwal, Rohit; Pistorio, Angela; Bayat, Nastaran; Erman, Brian; Feldman, Brian M.; Huber, Adam M.; Cimaz, Rolando; Cuttica, Rubén J.; de Oliveira, Sheila Knupp; Lindsley, Carol B.; Pilkington, Clarissa A.; Punaro, Marilynn; Ravelli, Angelo; Reed, Ann M.; Rouster-Stevens, Kelly; van Royen-Kerkhof, Annet; Dressler, Frank; Magalhaes, Claudia Saad; Constantin, Tamás; Davidson, Joyce E.; Magnusson, Bo; Russo, Ricardo; Villa, Luca; Rinaldi, Mariangela; Rockette, Howard; Lachenbruch, Peter A.; Miller, Frederick W.; Vencovsky, Jiri; Ruperto, Nicolino; Rider, Lisa G.; Ruperto, Nicolino; Miller, Frederick W.; Vencovsky, Jiri; Aggarwal, Rohit; Erman, Brian; Bayat, Nastaran; Pistorio, Angela; Huber, Adam M.; Feldman, Brian M.; Hansen, Paul; Rockette, Howard; Lachenbruch, Peter A.; Ruperto, Nicolino; Rider, Lisa G.; Apaz, Maria; Bowyer, Suzanne; Cimaz, Rolando; Constantin, Tamás; Curran, Megan; Davidson, Joyce; Feldman, Brian M.; Griffin, Thomas; Huber, Adam H.; Jones, Olcay; Kim, Susan; Lang, Bianca; Lindsley, Carol; Lovell, Daniel; Saad Magalhaes, Claudia; Pachman, Lauren M.; Pilkington, Clarissa; Ponyi, Andrea; Punaro, Marilynn; Quartier, Pierre; Ramanan, Athimalaipet V.; Ravelli, Angelo; Reed, Ann; Rennebohm, Robert; Sherry, David D.; Silva, Clovis A.; Stringer, Elizabeth; van Royen-Kerkhof, Annet; Wallace, Carol; Miller, Frederick W.; Oddis, Chester V.; Reed, Ann; Rider, Lisa G.; Ruperto, Nicolino; Apaz, Maria; Avcin, Tadej; Becker, Mara; Beresford, Michael W.; Cimaz, Rolando; Constantin, Tamás; Curran, Megan; Cuttica, Ruben; Davidson, Joyce; Dressler, Frank; Dvergsten, Jeffrey; Feitosa de Oliveira, Sheila Knupp; Feldman, Brian M.; Leme Ferriani, Virginia Paes; Flato, Berit; Gerloni, Valeria; Griffin, Thomas; Henrickson, Michael; Hinze, Claas; Hoeltzel, Mark; Huber, Adam M.; Ibarra, Maria; Ilowite, Norman; Imundo, Lisa; Jones, Olcay; Kim, Susan; Kingsbury, Daniel; Lang, Bianca; Lindsley, Carol; Lovell, Daniel; Martini, Alberto; Saad Magalhaes, Claudia; Magnusson, Bo; Maguiness, Sheilagh; Maillard, Susan; Mathiesen, Pernille; McCann, Liza; Nielsen, Susan; Pachman, Lauren M.; Passo, Murray; Pilkington, Clarissa; Punaro, Marilynn; Quartier, Pierre; Rabinovich, Egla; Ramanan, Athimalaipet V.; Ravelli, Angelo; Reed, Ann; Rennebohm, Robert; Rider, Lisa G.; Rivas-Chacon, Rafael; Byun Robinson, Angela; Rouster-Stevens, Kelly; Russo, Ricardo; Rutkowska-Sak, Lidia; Sallum, Adriana; Sanner, Helga; Schmeling, Heinrike; Selcen, Duygu; Shaham, Bracha; Sherry, David D.; Silva, Clovis A.; Spencer, Charles H.; Sundel, Robert; Tardieu, Marc; Thatayatikom, Akaluck; van der Net, Janjaap; van Royen-Kerkhof, Annet; Wahezi, Dawn; Wallace, Carol; Zulian, Francesco; analysis, Conjoint; Cimaz, Rolando; Constantin, Tamás; Cuttica, Ruben; Davidson, Joyce; Dressler, Frank; Knupp Feitosa de Oliveira, Sheila; Feldman, Brian M.; Griffin, Thomas; Henrickson, Michael; Huber, Adam M.; Imundo, Lisa; Lang, Bianca; Lindsley, Carol; Saad Magalhaes, Claudia; Magnusson, Bo; Maillard, Susan; Pachman, Lauren M.; Passo, Murray; Pilkington, Clarissa; Punaro, Marilynn; Ravelli, Angelo; Reed, Ann; Rider, Lisa G.; Rouster-Stevens, Kelly; Russo, Ricardo; Shaham, Bracha; Sundel, Robert; van der Net, Janjaap; van Royen-Kerkhof, Annet; Cimaz, Rolando; Cuttica, Rubén; Knupp Feitosa de Oliveira, Sheila; Feldman, Brian M.; Huber, Adam M.; Lindsley, Carol B.; Pilkington, Clarissa; Punaro, Marilynn; Ravelli, Angelo; Reed, Ann; Rouster-Stevens, Kelly; van Royen-Kerkhof, Annet; Amato, Anthony; Chinoy, Hector; Cooper, Robert G.; Dastmalchi, Maryam; de Visser, Marianne; Fiorentino, David; Isenberg, David; Katz, James; Mammen, Andrew; Oddis, Chester V.; Vencovsky, Jiri; Ytterberg, Steven R.; for the International Myositis Assessment and Clinical Studies Group and the Paediatric Rheumatology International Trials Organisation / 2016 American College of Rheumatology/European League Against Rheumatism Criteria for Minimal, Moderate, and Major Clinical Response in Juvenile Dermatomyositis : An International Myositis Assessment and Clinical Studies Group/Paediatric Rheumatology International Trials Organisation Collaborative Initiative.

In: Arthritis and Rheumatology, Vol. 69, No. 5, 01.05.2017, p. 911-923.

Research output: Contribution to journalArticle

@article{010d7e92d17345b8a9860eb32c532a89,
title = "2016 American College of Rheumatology/European League Against Rheumatism Criteria for Minimal, Moderate, and Major Clinical Response in Juvenile Dermatomyositis: An International Myositis Assessment and Clinical Studies Group/Paediatric Rheumatology International Trials Organisation Collaborative Initiative",
abstract = "Objective: To develop response criteria for juvenile dermatomyositis (DM). Methods: We analyzed the performance of 312 definitions that used core set measures from either the International Myositis Assessment and Clinical Studies Group (IMACS) or the Paediatric Rheumatology International Trials Organisation (PRINTO) and were derived from natural history data and a conjoint analysis survey. They were further validated using data from the PRINTO trial of prednisone alone compared to prednisone with methotrexate or cyclosporine and the Rituximab in Myositis (RIM) trial. At a consensus conference, experts considered 14 top candidate criteria based on their performance characteristics and clinical face validity, using nominal group technique. Results: Consensus was reached for a conjoint analysis–based continuous model with a total improvement score of 0–100, using absolute percent change in core set measures of minimal (≥30), moderate (≥45), and major (≥70) improvement. The same criteria were chosen for adult DM/polymyositis, with differing thresholds for improvement. The sensitivity and specificity were 89% and 91–98% for minimal improvement, 92–94% and 94–99% for moderate improvement, and 91–98% and 85–86% for major improvement, respectively, in juvenile DM patient cohorts using the IMACS and PRINTO core set measures. These criteria were validated in the PRINTO trial for differentiating between treatment arms for minimal and moderate improvement (P = 0.009–0.057) and in the RIM trial for significantly differentiating the physician's rating for improvement (P < 0.006). Conclusion: The response criteria for juvenile DM consisted of a conjoint analysis–based model using a continuous improvement score based on absolute percent change in core set measures, with thresholds for minimal, moderate, and major improvement.",
author = "Rider, {Lisa G.} and Rohit Aggarwal and Angela Pistorio and Nastaran Bayat and Brian Erman and Feldman, {Brian M.} and Huber, {Adam M.} and Rolando Cimaz and Cuttica, {Rubén J.} and {de Oliveira}, {Sheila Knupp} and Lindsley, {Carol B.} and Pilkington, {Clarissa A.} and Marilynn Punaro and Angelo Ravelli and Reed, {Ann M.} and Kelly Rouster-Stevens and {van Royen-Kerkhof}, Annet and Frank Dressler and Magalhaes, {Claudia Saad} and Tamás Constantin and Davidson, {Joyce E.} and Bo Magnusson and Ricardo Russo and Luca Villa and Mariangela Rinaldi and Howard Rockette and Lachenbruch, {Peter A.} and Miller, {Frederick W.} and Jiri Vencovsky and Nicolino Ruperto and Rider, {Lisa G.} and Nicolino Ruperto and Miller, {Frederick W.} and Jiri Vencovsky and Rohit Aggarwal and Brian Erman and Nastaran Bayat and Angela Pistorio and Huber, {Adam M.} and Feldman, {Brian M.} and Paul Hansen and Howard Rockette and Lachenbruch, {Peter A.} and Nicolino Ruperto and Rider, {Lisa G.} and Maria Apaz and Suzanne Bowyer and Rolando Cimaz and Tamás Constantin and Megan Curran and Joyce Davidson and Feldman, {Brian M.} and Thomas Griffin and Huber, {Adam H.} and Olcay Jones and Susan Kim and Bianca Lang and Carol Lindsley and Daniel Lovell and {Saad Magalhaes}, Claudia and Pachman, {Lauren M.} and Clarissa Pilkington and Andrea Ponyi and Marilynn Punaro and Pierre Quartier and Ramanan, {Athimalaipet V.} and Angelo Ravelli and Ann Reed and Robert Rennebohm and Sherry, {David D.} and Silva, {Clovis A.} and Elizabeth Stringer and {van Royen-Kerkhof}, Annet and Carol Wallace and Miller, {Frederick W.} and Oddis, {Chester V.} and Ann Reed and Rider, {Lisa G.} and Nicolino Ruperto and Maria Apaz and Tadej Avcin and Mara Becker and Beresford, {Michael W.} and Rolando Cimaz and Tamás Constantin and Megan Curran and Ruben Cuttica and Joyce Davidson and Frank Dressler and Jeffrey Dvergsten and {Feitosa de Oliveira}, {Sheila Knupp} and Feldman, {Brian M.} and {Leme Ferriani}, {Virginia Paes} and Berit Flato and Valeria Gerloni and Thomas Griffin and Michael Henrickson and Claas Hinze and Mark Hoeltzel and Huber, {Adam M.} and Maria Ibarra and Norman Ilowite and Lisa Imundo and Olcay Jones and Susan Kim and Daniel Kingsbury and Bianca Lang and Carol Lindsley and Daniel Lovell and Alberto Martini and {Saad Magalhaes}, Claudia and Bo Magnusson and Sheilagh Maguiness and Susan Maillard and Pernille Mathiesen and Liza McCann and Susan Nielsen and Pachman, {Lauren M.} and Murray Passo and Clarissa Pilkington and Marilynn Punaro and Pierre Quartier and Egla Rabinovich and Ramanan, {Athimalaipet V.} and Angelo Ravelli and Ann Reed and Robert Rennebohm and Rider, {Lisa G.} and Rafael Rivas-Chacon and {Byun Robinson}, Angela and Kelly Rouster-Stevens and Ricardo Russo and Lidia Rutkowska-Sak and Adriana Sallum and Helga Sanner and Heinrike Schmeling and Duygu Selcen and Bracha Shaham and Sherry, {David D.} and Silva, {Clovis A.} and Spencer, {Charles H.} and Robert Sundel and Marc Tardieu and Akaluck Thatayatikom and {van der Net}, Janjaap and {van Royen-Kerkhof}, Annet and Dawn Wahezi and Carol Wallace and Francesco Zulian and Conjoint analysis and Rolando Cimaz and Tamás Constantin and Ruben Cuttica and Joyce Davidson and Frank Dressler and {Knupp Feitosa de Oliveira}, Sheila and Feldman, {Brian M.} and Thomas Griffin and Michael Henrickson and Huber, {Adam M.} and Lisa Imundo and Bianca Lang and Carol Lindsley and {Saad Magalhaes}, Claudia and Bo Magnusson and Susan Maillard and Pachman, {Lauren M.} and Murray Passo and Clarissa Pilkington and Marilynn Punaro and Angelo Ravelli and Ann Reed and Rider, {Lisa G.} and Kelly Rouster-Stevens and Ricardo Russo and Bracha Shaham and Robert Sundel and {van der Net}, Janjaap and {van Royen-Kerkhof}, Annet and Rolando Cimaz and Rubén Cuttica and {Knupp Feitosa de Oliveira}, Sheila and Feldman, {Brian M.} and Huber, {Adam M.} and Lindsley, {Carol B.} and Clarissa Pilkington and Marilynn Punaro and Angelo Ravelli and Ann Reed and Kelly Rouster-Stevens and {van Royen-Kerkhof}, Annet and Anthony Amato and Hector Chinoy and Cooper, {Robert G.} and Maryam Dastmalchi and {de Visser}, Marianne and David Fiorentino and David Isenberg and James Katz and Andrew Mammen and Oddis, {Chester V.} and Jiri Vencovsky and Ytterberg, {Steven R.} and {for the International Myositis Assessment and Clinical Studies Group and the Paediatric Rheumatology International Trials Organisation}",
year = "2017",
month = "5",
doi = "10.1002/art.40060",
volume = "69",
pages = "911--923",
journal = "Arthritis and Rheumatology",
issn = "2326-5191",
publisher = "John Wiley and Sons Ltd",
number = "5",

}

TY - JOUR

T1 - 2016 American College of Rheumatology/European League Against Rheumatism Criteria for Minimal, Moderate, and Major Clinical Response in Juvenile Dermatomyositis

T2 - Arthritis and Rheumatology

AU - Rider,Lisa G.

AU - Aggarwal,Rohit

AU - Pistorio,Angela

AU - Bayat,Nastaran

AU - Erman,Brian

AU - Feldman,Brian M.

AU - Huber,Adam M.

AU - Cimaz,Rolando

AU - Cuttica,Rubén J.

AU - de Oliveira,Sheila Knupp

AU - Lindsley,Carol B.

AU - Pilkington,Clarissa A.

AU - Punaro,Marilynn

AU - Ravelli,Angelo

AU - Reed,Ann M.

AU - Rouster-Stevens,Kelly

AU - van Royen-Kerkhof,Annet

AU - Dressler,Frank

AU - Magalhaes,Claudia Saad

AU - Constantin,Tamás

AU - Davidson,Joyce E.

AU - Magnusson,Bo

AU - Russo,Ricardo

AU - Villa,Luca

AU - Rinaldi,Mariangela

AU - Rockette,Howard

AU - Lachenbruch,Peter A.

AU - Miller,Frederick W.

AU - Vencovsky,Jiri

AU - Ruperto,Nicolino

AU - Rider,Lisa G.

AU - Ruperto,Nicolino

AU - Miller,Frederick W.

AU - Vencovsky,Jiri

AU - Aggarwal,Rohit

AU - Erman,Brian

AU - Bayat,Nastaran

AU - Pistorio,Angela

AU - Huber,Adam M.

AU - Feldman,Brian M.

AU - Hansen,Paul

AU - Rockette,Howard

AU - Lachenbruch,Peter A.

AU - Ruperto,Nicolino

AU - Rider,Lisa G.

AU - Apaz,Maria

AU - Bowyer,Suzanne

AU - Cimaz,Rolando

AU - Constantin,Tamás

AU - Curran,Megan

AU - Davidson,Joyce

AU - Feldman,Brian M.

AU - Griffin,Thomas

AU - Huber,Adam H.

AU - Jones,Olcay

AU - Kim,Susan

AU - Lang,Bianca

AU - Lindsley,Carol

AU - Lovell,Daniel

AU - Saad Magalhaes,Claudia

AU - Pachman,Lauren M.

AU - Pilkington,Clarissa

AU - Ponyi,Andrea

AU - Punaro,Marilynn

AU - Quartier,Pierre

AU - Ramanan,Athimalaipet V.

AU - Ravelli,Angelo

AU - Reed,Ann

AU - Rennebohm,Robert

AU - Sherry,David D.

AU - Silva,Clovis A.

AU - Stringer,Elizabeth

AU - van Royen-Kerkhof,Annet

AU - Wallace,Carol

AU - Miller,Frederick W.

AU - Oddis,Chester V.

AU - Reed,Ann

AU - Rider,Lisa G.

AU - Ruperto,Nicolino

AU - Apaz,Maria

AU - Avcin,Tadej

AU - Becker,Mara

AU - Beresford,Michael W.

AU - Cimaz,Rolando

AU - Constantin,Tamás

AU - Curran,Megan

AU - Cuttica,Ruben

AU - Davidson,Joyce

AU - Dressler,Frank

AU - Dvergsten,Jeffrey

AU - Feitosa de Oliveira,Sheila Knupp

AU - Feldman,Brian M.

AU - Leme Ferriani,Virginia Paes

AU - Flato,Berit

AU - Gerloni,Valeria

AU - Griffin,Thomas

AU - Henrickson,Michael

AU - Hinze,Claas

AU - Hoeltzel,Mark

AU - Huber,Adam M.

AU - Ibarra,Maria

AU - Ilowite,Norman

AU - Imundo,Lisa

AU - Jones,Olcay

AU - Kim,Susan

AU - Kingsbury,Daniel

AU - Lang,Bianca

AU - Lindsley,Carol

AU - Lovell,Daniel

AU - Martini,Alberto

AU - Saad Magalhaes,Claudia

AU - Magnusson,Bo

AU - Maguiness,Sheilagh

AU - Maillard,Susan

AU - Mathiesen,Pernille

AU - McCann,Liza

AU - Nielsen,Susan

AU - Pachman,Lauren M.

AU - Passo,Murray

AU - Pilkington,Clarissa

AU - Punaro,Marilynn

AU - Quartier,Pierre

AU - Rabinovich,Egla

AU - Ramanan,Athimalaipet V.

AU - Ravelli,Angelo

AU - Reed,Ann

AU - Rennebohm,Robert

AU - Rider,Lisa G.

AU - Rivas-Chacon,Rafael

AU - Byun Robinson,Angela

AU - Rouster-Stevens,Kelly

AU - Russo,Ricardo

AU - Rutkowska-Sak,Lidia

AU - Sallum,Adriana

AU - Sanner,Helga

AU - Schmeling,Heinrike

AU - Selcen,Duygu

AU - Shaham,Bracha

AU - Sherry,David D.

AU - Silva,Clovis A.

AU - Spencer,Charles H.

AU - Sundel,Robert

AU - Tardieu,Marc

AU - Thatayatikom,Akaluck

AU - van der Net,Janjaap

AU - van Royen-Kerkhof,Annet

AU - Wahezi,Dawn

AU - Wallace,Carol

AU - Zulian,Francesco

AU - analysis,Conjoint

AU - Cimaz,Rolando

AU - Constantin,Tamás

AU - Cuttica,Ruben

AU - Davidson,Joyce

AU - Dressler,Frank

AU - Knupp Feitosa de Oliveira,Sheila

AU - Feldman,Brian M.

AU - Griffin,Thomas

AU - Henrickson,Michael

AU - Huber,Adam M.

AU - Imundo,Lisa

AU - Lang,Bianca

AU - Lindsley,Carol

AU - Saad Magalhaes,Claudia

AU - Magnusson,Bo

AU - Maillard,Susan

AU - Pachman,Lauren M.

AU - Passo,Murray

AU - Pilkington,Clarissa

AU - Punaro,Marilynn

AU - Ravelli,Angelo

AU - Reed,Ann

AU - Rider,Lisa G.

AU - Rouster-Stevens,Kelly

AU - Russo,Ricardo

AU - Shaham,Bracha

AU - Sundel,Robert

AU - van der Net,Janjaap

AU - van Royen-Kerkhof,Annet

AU - Cimaz,Rolando

AU - Cuttica,Rubén

AU - Knupp Feitosa de Oliveira,Sheila

AU - Feldman,Brian M.

AU - Huber,Adam M.

AU - Lindsley,Carol B.

AU - Pilkington,Clarissa

AU - Punaro,Marilynn

AU - Ravelli,Angelo

AU - Reed,Ann

AU - Rouster-Stevens,Kelly

AU - van Royen-Kerkhof,Annet

AU - Amato,Anthony

AU - Chinoy,Hector

AU - Cooper,Robert G.

AU - Dastmalchi,Maryam

AU - de Visser,Marianne

AU - Fiorentino,David

AU - Isenberg,David

AU - Katz,James

AU - Mammen,Andrew

AU - Oddis,Chester V.

AU - Vencovsky,Jiri

AU - Ytterberg,Steven R.

AU - for the International Myositis Assessment and Clinical Studies Group and the Paediatric Rheumatology International Trials Organisation

PY - 2017/5/1

Y1 - 2017/5/1

N2 - Objective: To develop response criteria for juvenile dermatomyositis (DM). Methods: We analyzed the performance of 312 definitions that used core set measures from either the International Myositis Assessment and Clinical Studies Group (IMACS) or the Paediatric Rheumatology International Trials Organisation (PRINTO) and were derived from natural history data and a conjoint analysis survey. They were further validated using data from the PRINTO trial of prednisone alone compared to prednisone with methotrexate or cyclosporine and the Rituximab in Myositis (RIM) trial. At a consensus conference, experts considered 14 top candidate criteria based on their performance characteristics and clinical face validity, using nominal group technique. Results: Consensus was reached for a conjoint analysis–based continuous model with a total improvement score of 0–100, using absolute percent change in core set measures of minimal (≥30), moderate (≥45), and major (≥70) improvement. The same criteria were chosen for adult DM/polymyositis, with differing thresholds for improvement. The sensitivity and specificity were 89% and 91–98% for minimal improvement, 92–94% and 94–99% for moderate improvement, and 91–98% and 85–86% for major improvement, respectively, in juvenile DM patient cohorts using the IMACS and PRINTO core set measures. These criteria were validated in the PRINTO trial for differentiating between treatment arms for minimal and moderate improvement (P = 0.009–0.057) and in the RIM trial for significantly differentiating the physician's rating for improvement (P < 0.006). Conclusion: The response criteria for juvenile DM consisted of a conjoint analysis–based model using a continuous improvement score based on absolute percent change in core set measures, with thresholds for minimal, moderate, and major improvement.

AB - Objective: To develop response criteria for juvenile dermatomyositis (DM). Methods: We analyzed the performance of 312 definitions that used core set measures from either the International Myositis Assessment and Clinical Studies Group (IMACS) or the Paediatric Rheumatology International Trials Organisation (PRINTO) and were derived from natural history data and a conjoint analysis survey. They were further validated using data from the PRINTO trial of prednisone alone compared to prednisone with methotrexate or cyclosporine and the Rituximab in Myositis (RIM) trial. At a consensus conference, experts considered 14 top candidate criteria based on their performance characteristics and clinical face validity, using nominal group technique. Results: Consensus was reached for a conjoint analysis–based continuous model with a total improvement score of 0–100, using absolute percent change in core set measures of minimal (≥30), moderate (≥45), and major (≥70) improvement. The same criteria were chosen for adult DM/polymyositis, with differing thresholds for improvement. The sensitivity and specificity were 89% and 91–98% for minimal improvement, 92–94% and 94–99% for moderate improvement, and 91–98% and 85–86% for major improvement, respectively, in juvenile DM patient cohorts using the IMACS and PRINTO core set measures. These criteria were validated in the PRINTO trial for differentiating between treatment arms for minimal and moderate improvement (P = 0.009–0.057) and in the RIM trial for significantly differentiating the physician's rating for improvement (P < 0.006). Conclusion: The response criteria for juvenile DM consisted of a conjoint analysis–based model using a continuous improvement score based on absolute percent change in core set measures, with thresholds for minimal, moderate, and major improvement.

UR - http://www.scopus.com/inward/record.url?scp=85017506720&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85017506720&partnerID=8YFLogxK

U2 - 10.1002/art.40060

DO - 10.1002/art.40060

M3 - Article

VL - 69

SP - 911

EP - 923

JO - Arthritis and Rheumatology

JF - Arthritis and Rheumatology

SN - 2326-5191

IS - 5

ER -