Abstract

Purpose: To develop 3D high-resolution imaging of 2-hydroxyglutarate (2HG) at 3T in vivo. Methods: Echo-planar spectroscopic imaging with dual-readout alternated-gradients (DRAG-EPSI), which was recently reported for 2D imaging of 2HG at 7T, was tested for 3D imaging of 2HG at 3T. The frequency drifts and acoustic noise induced by DRAG-EPSI were investigated in comparison with conventional EPSI. Four patients with IDH-mutant gliomas were enrolled for 3D imaging of 2HG and other metabolites. A previously reported 2HG-tailored TE 97-ms PRESS sequence preceded the DRAG-EPSI readout gradients. Unsuppressed water, acquired with EPSI, was used as reference for multi-channel combination, eddy-current compensation, and metabolite quantification. Spectral fitting was conducted with the LCModel using in-house basis sets. Results: With gradient strength of 4 mT/m and slew rate of 20 mT/m/ms, DRAG-EPSI produced frequency drifts smaller by 5.5-fold and acoustic noise lower by 25 dB compared to conventional EPSI. In a 19-min scan, 3D DRAG-EPSI provided images of 2HG with precision (CRLB <10%) at a resolution of 10 × 10 × 10 mm3 for a field of view of 240 × 180 × 80 mm3. 2HG was estimated to be 5 mM in a pre-treatment patient. In 3 post-surgery patients, 2HG estimates were 3–6 mM, and the 2HG distribution was different from the water-T2 image pattern or highly concentrated in the post-contrast enhancing region. Conclusion: Together with 2HG-optimized PRESS, DRAG-EPSI provides an effective tool for reliable 3D high-resolution imaging of 2HG at 3T in vivo.

LanguageEnglish (US)
JournalMagnetic Resonance in Medicine
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

Glioma
Acoustics
Noise
alpha-hydroxyglutarate
Echo-Planar Imaging
Water

Keywords

  • H MRS
  • 2-hydroxyglutarate (2HG)
  • 3T
  • dual-readout alternated-gradients EPSI (DRAG-EPSI)
  • echo-planar spectroscopy imaging (EPSI)
  • glioma
  • human brain tumor

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

@article{0569ba7748334ad6aa88651bda49aa89,
title = "3D high-resolution imaging of 2-hydroxyglutarate in glioma patients using DRAG-EPSI at 3T in vivo",
abstract = "Purpose: To develop 3D high-resolution imaging of 2-hydroxyglutarate (2HG) at 3T in vivo. Methods: Echo-planar spectroscopic imaging with dual-readout alternated-gradients (DRAG-EPSI), which was recently reported for 2D imaging of 2HG at 7T, was tested for 3D imaging of 2HG at 3T. The frequency drifts and acoustic noise induced by DRAG-EPSI were investigated in comparison with conventional EPSI. Four patients with IDH-mutant gliomas were enrolled for 3D imaging of 2HG and other metabolites. A previously reported 2HG-tailored TE 97-ms PRESS sequence preceded the DRAG-EPSI readout gradients. Unsuppressed water, acquired with EPSI, was used as reference for multi-channel combination, eddy-current compensation, and metabolite quantification. Spectral fitting was conducted with the LCModel using in-house basis sets. Results: With gradient strength of 4 mT/m and slew rate of 20 mT/m/ms, DRAG-EPSI produced frequency drifts smaller by 5.5-fold and acoustic noise lower by 25 dB compared to conventional EPSI. In a 19-min scan, 3D DRAG-EPSI provided images of 2HG with precision (CRLB <10{\%}) at a resolution of 10 × 10 × 10 mm3 for a field of view of 240 × 180 × 80 mm3. 2HG was estimated to be 5 mM in a pre-treatment patient. In 3 post-surgery patients, 2HG estimates were 3–6 mM, and the 2HG distribution was different from the water-T2 image pattern or highly concentrated in the post-contrast enhancing region. Conclusion: Together with 2HG-optimized PRESS, DRAG-EPSI provides an effective tool for reliable 3D high-resolution imaging of 2HG at 3T in vivo.",
keywords = "H MRS, 2-hydroxyglutarate (2HG), 3T, dual-readout alternated-gradients EPSI (DRAG-EPSI), echo-planar spectroscopy imaging (EPSI), glioma, human brain tumor",
author = "Zhongxu An and Vivek Tiwari and Jeannie Baxter and Michael Levy and Hatanpaa, {Kimmo J.} and Edward Pan and Maher, {Elizabeth A.} and Patel, {Toral R.} and Mickey, {Bruce E.} and Changho Choi",
year = "2018",
month = "1",
day = "1",
doi = "10.1002/mrm.27482",
language = "English (US)",
journal = "Magnetic Resonance in Medicine",
issn = "0740-3194",
publisher = "John Wiley and Sons Inc.",

}

TY - JOUR

T1 - 3D high-resolution imaging of 2-hydroxyglutarate in glioma patients using DRAG-EPSI at 3T in vivo

AU - An, Zhongxu

AU - Tiwari, Vivek

AU - Baxter, Jeannie

AU - Levy, Michael

AU - Hatanpaa, Kimmo J.

AU - Pan, Edward

AU - Maher, Elizabeth A.

AU - Patel, Toral R.

AU - Mickey, Bruce E.

AU - Choi, Changho

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Purpose: To develop 3D high-resolution imaging of 2-hydroxyglutarate (2HG) at 3T in vivo. Methods: Echo-planar spectroscopic imaging with dual-readout alternated-gradients (DRAG-EPSI), which was recently reported for 2D imaging of 2HG at 7T, was tested for 3D imaging of 2HG at 3T. The frequency drifts and acoustic noise induced by DRAG-EPSI were investigated in comparison with conventional EPSI. Four patients with IDH-mutant gliomas were enrolled for 3D imaging of 2HG and other metabolites. A previously reported 2HG-tailored TE 97-ms PRESS sequence preceded the DRAG-EPSI readout gradients. Unsuppressed water, acquired with EPSI, was used as reference for multi-channel combination, eddy-current compensation, and metabolite quantification. Spectral fitting was conducted with the LCModel using in-house basis sets. Results: With gradient strength of 4 mT/m and slew rate of 20 mT/m/ms, DRAG-EPSI produced frequency drifts smaller by 5.5-fold and acoustic noise lower by 25 dB compared to conventional EPSI. In a 19-min scan, 3D DRAG-EPSI provided images of 2HG with precision (CRLB <10%) at a resolution of 10 × 10 × 10 mm3 for a field of view of 240 × 180 × 80 mm3. 2HG was estimated to be 5 mM in a pre-treatment patient. In 3 post-surgery patients, 2HG estimates were 3–6 mM, and the 2HG distribution was different from the water-T2 image pattern or highly concentrated in the post-contrast enhancing region. Conclusion: Together with 2HG-optimized PRESS, DRAG-EPSI provides an effective tool for reliable 3D high-resolution imaging of 2HG at 3T in vivo.

AB - Purpose: To develop 3D high-resolution imaging of 2-hydroxyglutarate (2HG) at 3T in vivo. Methods: Echo-planar spectroscopic imaging with dual-readout alternated-gradients (DRAG-EPSI), which was recently reported for 2D imaging of 2HG at 7T, was tested for 3D imaging of 2HG at 3T. The frequency drifts and acoustic noise induced by DRAG-EPSI were investigated in comparison with conventional EPSI. Four patients with IDH-mutant gliomas were enrolled for 3D imaging of 2HG and other metabolites. A previously reported 2HG-tailored TE 97-ms PRESS sequence preceded the DRAG-EPSI readout gradients. Unsuppressed water, acquired with EPSI, was used as reference for multi-channel combination, eddy-current compensation, and metabolite quantification. Spectral fitting was conducted with the LCModel using in-house basis sets. Results: With gradient strength of 4 mT/m and slew rate of 20 mT/m/ms, DRAG-EPSI produced frequency drifts smaller by 5.5-fold and acoustic noise lower by 25 dB compared to conventional EPSI. In a 19-min scan, 3D DRAG-EPSI provided images of 2HG with precision (CRLB <10%) at a resolution of 10 × 10 × 10 mm3 for a field of view of 240 × 180 × 80 mm3. 2HG was estimated to be 5 mM in a pre-treatment patient. In 3 post-surgery patients, 2HG estimates were 3–6 mM, and the 2HG distribution was different from the water-T2 image pattern or highly concentrated in the post-contrast enhancing region. Conclusion: Together with 2HG-optimized PRESS, DRAG-EPSI provides an effective tool for reliable 3D high-resolution imaging of 2HG at 3T in vivo.

KW - H MRS

KW - 2-hydroxyglutarate (2HG)

KW - 3T

KW - dual-readout alternated-gradients EPSI (DRAG-EPSI)

KW - echo-planar spectroscopy imaging (EPSI)

KW - glioma

KW - human brain tumor

UR - http://www.scopus.com/inward/record.url?scp=85053476920&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85053476920&partnerID=8YFLogxK

U2 - 10.1002/mrm.27482

DO - 10.1002/mrm.27482

M3 - Article

JO - Magnetic Resonance in Medicine

T2 - Magnetic Resonance in Medicine

JF - Magnetic Resonance in Medicine

SN - 0740-3194

ER -