BOLD hemodynamic response function changes significantly with healthy aging

Kathryn L. West, Mark D. Zuppichini, Monroe P. Turner, Dinesh K. Sivakolundu, Yuguang Zhao, Dema Abdelkarim, Jeffrey S. Spence, Bart Rypma

Research output: Contribution to journalArticle

Abstract

Functional magnetic resonance imaging (fMRI) has been used to infer age-differences in neural activity from the hemodynamic response function (HRF) that characterizes the blood-oxygen-level-dependent (BOLD) signal over time. BOLD literature in healthy aging lacks consensus in age-related HRF changes, the nature of those changes, and their implications for measurement of age differences in brain function. Between-study discrepancies could be due to small sample sizes, analysis techniques, and/or physiologic mechanisms. We hypothesize that, with large sample sizes and minimal analysis assumptions, age-related changes in HRF parameters could reflect alterations in one or more components of the neural-vascular coupling system. To assess HRF changes in healthy aging, we analyzed the large population-derived dataset from the Cambridge Center for Aging and Neuroscience (CamCAN) study (Shafto et al., 2014). During scanning, 74 younger (18–30 years of age) and 173 older participants (54–74 years of age) viewed two checkerboards to the left and right of a central fixation point, simultaneously heard a binaural tone, and responded via right index finger button-press. To assess differences in the shape of the HRF between younger and older groups, HRFs were estimated using FMRIB's Linear Optimal Basis Sets (FLOBS) to minimize a priori shape assumptions. Group mean HRFs were different between younger and older groups in auditory, visual, and motor cortices. Specifically, we observed increased time-to-peak and decreased peak amplitude in older compared to younger adults in auditory, visual, and motor cortices. Changes in the shape and timing of the HRF in healthy aging, in the absence of performance differences, support our hypothesis of age-related changes in the neural-vascular coupling system beyond neural activity alone. More precise interpretations of HRF age-differences can be formulated once these physiologic factors are disentangled and measured separately.

LanguageEnglish (US)
Pages198-207
Number of pages10
JournalNeuroImage
Volume188
DOIs
StatePublished - Mar 1 2019

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Hemodynamics
Oxygen
Auditory Cortex
Motor Cortex
Visual Cortex
Sample Size
Blood Vessels
Neurosciences
Fingers
Young Adult
Magnetic Resonance Imaging
Brain
Population

ASJC Scopus subject areas

  • Neurology
  • Cognitive Neuroscience

Cite this

West, K. L., Zuppichini, M. D., Turner, M. P., Sivakolundu, D. K., Zhao, Y., Abdelkarim, D., ... Rypma, B. (2019). BOLD hemodynamic response function changes significantly with healthy aging. NeuroImage, 188, 198-207. https://doi.org/10.1016/j.neuroimage.2018.12.012

BOLD hemodynamic response function changes significantly with healthy aging. / West, Kathryn L.; Zuppichini, Mark D.; Turner, Monroe P.; Sivakolundu, Dinesh K.; Zhao, Yuguang; Abdelkarim, Dema; Spence, Jeffrey S.; Rypma, Bart.

In: NeuroImage, Vol. 188, 01.03.2019, p. 198-207.

Research output: Contribution to journalArticle

West, KL, Zuppichini, MD, Turner, MP, Sivakolundu, DK, Zhao, Y, Abdelkarim, D, Spence, JS & Rypma, B 2019, 'BOLD hemodynamic response function changes significantly with healthy aging' NeuroImage, vol. 188, pp. 198-207. https://doi.org/10.1016/j.neuroimage.2018.12.012
West KL, Zuppichini MD, Turner MP, Sivakolundu DK, Zhao Y, Abdelkarim D et al. BOLD hemodynamic response function changes significantly with healthy aging. NeuroImage. 2019 Mar 1;188:198-207. https://doi.org/10.1016/j.neuroimage.2018.12.012
West, Kathryn L. ; Zuppichini, Mark D. ; Turner, Monroe P. ; Sivakolundu, Dinesh K. ; Zhao, Yuguang ; Abdelkarim, Dema ; Spence, Jeffrey S. ; Rypma, Bart. / BOLD hemodynamic response function changes significantly with healthy aging. In: NeuroImage. 2019 ; Vol. 188. pp. 198-207.
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