Minireview: Fetal-maternal hormonal signaling in pregnancy and labor

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Abstract

Mechanisms underlying the initiation of parturition remain unclear. Throughout most of pregnancy, uterine quiescence is maintained by elevated progesterone acting through progesterone receptor (PR). Although in most mammals, parturition is associated with a marked decline in maternal progesterone, in humans, circulating progesterone and uterine PR remain elevated throughout pregnancy, suggesting a critical role for functional PR inactivation in the initiation of labor. Both term and preterm labor in humans and rodents are associated with an inflammatory response. In preterm labor, intraamniotic infection likely provides the stimulus for increased amniotic fluid interleukins and migration of inflammatory cells into the uterus and cervix. However, at term, the stimulus for this inflammatory response is unknown. Increasing evidence suggests that the developing fetus may produce physical and hormonal signals that stimulate macrophage migration to the uterus, with release of cytokines and activation of inflammatory transcription factors, such as nuclear factor κB (NF-κB) and activator protein 1 (AP-1), which also is activated by myometrial stretch. We postulate that the increased inflammatory response and NF-κB activation promote uterine contractility via 1) direct activation of contractile genes (e.g. COX-2, oxytocin receptor, and connexin 43) and 2) impairment of the capacity of PR to mediate uterine quiescence. PR function near term may be compromised by direct interaction with NF-κB, altered expression of PR coregulators, increased metabolism of progesterone within the cervix and myometrium, and increased expression of inhibitory PR isoforms. Alternatively, we propose that uterine quiescence during pregnancy is regulated, in part, by PR antagonism of the inflammatory response.

LanguageEnglish (US)
Pages947-954
Number of pages8
JournalMolecular Endocrinology
Volume23
Issue number7
DOIs
StatePublished - Jul 2009

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Progesterone Receptors
Mothers
Pregnancy
Progesterone
Premature Obstetric Labor
Cervix Uteri
Parturition
Oxytocin Receptors
Connexin 43
Myometrium
Interleukins
Transcription Factor AP-1
Amniotic Fluid
Transcriptional Activation
Uterus
Cell Movement
Mammals
Rodentia
Protein Isoforms
Fetus

ASJC Scopus subject areas

  • Molecular Biology
  • Endocrinology

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Minireview : Fetal-maternal hormonal signaling in pregnancy and labor. / Mendelson, Carole R.

In: Molecular Endocrinology, Vol. 23, No. 7, 07.2009, p. 947-954.

Research output: Contribution to journalArticle

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