Resident viruses and their interactions with the immune system

Breck A. Duerkop, Lora V. Hooper

Research output: Contribution to journalArticle

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Abstract

The human body is colonized with a diverse resident microflora that includes viruses. Recent studies of metagenomes have begun to characterize the composition of the human 'virobiota' and its associated genes (the 'virome'), and have fostered the emerging field of host-virobiota interactions. In this Perspective, we explore how resident viruses interact with the immune system. We review recent findings that highlight the role of the immune system in shaping the composition of the virobiota and consider how resident viruses may impact host immunity. Finally, we discuss the implications of virobiota-immune system interactions for human health.

Original languageEnglish (US)
Pages (from-to)654-659
Number of pages6
JournalNature Immunology
Volume14
Issue number7
DOIs
StatePublished - Jul 2013

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Immune System
Viruses
Metagenome
Human Body
Immunity
Health
Genes

ASJC Scopus subject areas

  • Immunology

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Resident viruses and their interactions with the immune system. / Duerkop, Breck A.; Hooper, Lora V.

In: Nature Immunology, Vol. 14, No. 7, 07.2013, p. 654-659.

Research output: Contribution to journalArticle

Duerkop, Breck A.; Hooper, Lora V. / Resident viruses and their interactions with the immune system.

In: Nature Immunology, Vol. 14, No. 7, 07.2013, p. 654-659.

Research output: Contribution to journalArticle

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