Skeletal Metastasis Evaluation: Value and Impact of PET/Computed Tomography on Diagnosis, Management and Prognosis

Stephen M. Broski, Jason R. Young, Ayse T. Kendi, Rathan Subramaniam

Research output: Contribution to journalReview article

Abstract

A number of PET agents are useful for evaluation of skeletal metastatic disease, and have significant advantages over 99mTc-MDP scintigraphy, including superior diagnostic accuracy, higher spatial resolution, and shorter imaging times- often with the ability to depict soft tissue local recurrence and metastasis in the same examination. While these agents have excellent diagnostic utility, they are not 100% specific for skeletal metastasis, and so normal patterns of biodistribution, benign osseous lesions that may demonstrate radiotracer uptake, and the significance of morphologic changes on CT such as osteolysis or osteosclerosis must be kept in mind to ensure accurate interpretation.

LanguageEnglish (US)
Pages103-120
Number of pages18
JournalPET Clinics
Volume14
Issue number1
DOIs
StatePublished - Jan 1 2019

Fingerprint

prognosis
metastasis
tomography
Tomography
Osteosclerosis
Neoplasm Metastasis
Technetium Tc 99m Medronate
Osteolysis
evaluation
Radionuclide Imaging
lesions
examination
spatial resolution
Recurrence
high resolution

Keywords

  • Choline
  • FDG
  • Fluciclovine
  • NaF
  • PET/CT
  • Skeletal metastasis

ASJC Scopus subject areas

  • Radiation
  • Radiology Nuclear Medicine and imaging

Cite this

Skeletal Metastasis Evaluation : Value and Impact of PET/Computed Tomography on Diagnosis, Management and Prognosis. / Broski, Stephen M.; Young, Jason R.; Kendi, Ayse T.; Subramaniam, Rathan.

In: PET Clinics, Vol. 14, No. 1, 01.01.2019, p. 103-120.

Research output: Contribution to journalReview article

Broski, Stephen M. ; Young, Jason R. ; Kendi, Ayse T. ; Subramaniam, Rathan. / Skeletal Metastasis Evaluation : Value and Impact of PET/Computed Tomography on Diagnosis, Management and Prognosis. In: PET Clinics. 2019 ; Vol. 14, No. 1. pp. 103-120.
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